loading...
 This Article 
   
 Share 
   
 Bibliographic References 
   
 Add to: 
 
Digg
Furl
Spurl
Blink
Simpy
Google
Del.icio.us
Y!MyWeb
 
 Search 
   
IEEE Computer Society Bioinformatics Conference (CSB'03)
Initial Large-scale Exploration of Protein-protein Interactions in Human Brain
Stanford, California
August 11-August 14
ISBN: 0-7695-2000-6
ASCII Text
x 
 
Jake Y. Chen, Andrey Y. Sivachenko, Russell Bell, Cornelia Kurschner, Irene Ota, Sudhir Sahasrabudhe, "Initial Large-scale Exploration of Protein-protein Interactions in Human Brain," Computational Systems Bioinformatics Conference, International IEEE Computer Society, pp. 229, IEEE Computer Society Bioinformatics Conference (CSB'03), 2003.
 
 
BibTex
x
 
@article{ 10.1109/CSB.2003.1227322,
author = {Jake Y. Chen and Andrey Y. Sivachenko and Russell Bell and Cornelia Kurschner and Irene Ota and Sudhir Sahasrabudhe},
title = {Initial Large-scale Exploration of Protein-protein Interactions in Human Brain},
journal ={Computational Systems Bioinformatics Conference, International IEEE Computer Society},
volume = {0},
year = {2003},
isbn = {0-7695-2000-6},
pages = {229},
doi = {http://doi.ieeecomputersociety.org/10.1109/CSB.2003.1227322},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
x 
 
TY - CONF
JO - Computational Systems Bioinformatics Conference, International IEEE Computer Society
TI - Initial Large-scale Exploration of Protein-protein Interactions in Human Brain
SN - 0-7695-2000-6
SP
EP
A1 - Jake Y. Chen,
A1 - Andrey Y. Sivachenko,
A1 - Russell Bell,
A1 - Cornelia Kurschner,
A1 - Irene Ota,
A1 - Sudhir Sahasrabudhe,
PY - 2003
KW - null
VL - 0
JA - Computational Systems Bioinformatics Conference, International IEEE Computer Society
ER -
 
Jake Y. Chen, Myriad Proteomics, Inc.
Andrey Y. Sivachenko, Myriad Proteomics, Inc.
Russell Bell, Myriad Proteomics, Inc.
Cornelia Kurschner, Myriad Proteomics, Inc.
Irene Ota, Myriad Proteomics, Inc.
Sudhir Sahasrabudhe, Myriad Proteomics, Inc.
Study of protein interaction networks is crucial to post-genomic systems biology. Aided by high-throughput screening technologies, biologists are rapidly accumulating protein-protein interaction data. Using a random yeast two-hybrid (R2H) process, we have performed large-scale yeast two-hybrid searches with approximately fifty thousand random human brain cDNA bait fragments against a human brain cDNA prey fragment library. From these searches, we have identified 13,656 unique protein-protein interaction pairs involving 4,473 distinct known human loci. In this paper, we have performed our initial characterization of the protein interaction network in human brain tissue. We have classified and characterized all identified interactions based on Gene Ontology (GO) annotation of interacting loci. We have also described the "scale-free" topological structure of the network.
Citation:
Jake Y. Chen, Andrey Y. Sivachenko, Russell Bell, Cornelia Kurschner, Irene Ota, Sudhir Sahasrabudhe, "Initial Large-scale Exploration of Protein-protein Interactions in Human Brain," csb, pp.229, IEEE Computer Society Bioinformatics Conference (CSB'03), 2003
Usage of this product signifies your acceptance of the Terms of Use.