Currently, most governments experience severe problems managing the large N tier, networked environment. While new IT technologies aiming at automating the deployment and maintenance of IT infrastructure are emerging, as manifested in the autonomic computing paradigm where the IT infrastructure and its components are self-managing, the technology alone still cannot solve the complex information system manageability problems for E-Government infrastructure. This paper proposes an information and knowledge management model that combines the benefit of autonomic computing system paradigm for self-managed infrastructure systems and an event-based awareness collaboration knowledge management approach for coordinating the infrastructure management processes. We hope it provides a more comprehensive guideline for managing E-Government information systems.