This paper describes scheduling optimizations in the Intel ? Itanium ? compiler to prevent cache penalties due to various micro-architectural effects on the Itanium 2 processor. This paper does not try to improve cache hit rates but to avoid penalties, which probably all processors have in one form or another, even in the case of cache hits. These optimizations make use of sophisticated methods for disambiguation of memory references, and this paper examines the performance improvement obtained by integrating these methods into the cache optimizations.