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Fourth IEEE Symposium on Bioinformatics and Bioengineering (BIBE'04)
Identifying the Combination of Genetic Factors that Determine Susceptibility to Cervical Cancer
Taichung, Taiwan, ROC
May 19-May 21
ISBN: 0-7695-2173-8
Jorng-Tzong Horng, National Central University, Taiwan; National Central University, Taiwan
Kai-Chih Hu, National Central University, Taiwan
Li-Cheng Wu, National Central University, Taiwan
Hsien-Da Huang, National Chiao-Tung University, Taiwan
Horn-Cheng Lai, Tri-Service General Hospital, Taiwan
Ton-Yuen Chu, Tri-Service General Hospital, Taiwan
Cervical cancer is common among women all over the world. Although infection with high-risk types of human papillomavirus (HPV) has been identified as the primary cause of cervical cancer, only some of those infected go on to develop cervical cancer. Obviously, the progression from HPV infection to cancer involves other environmental and host factors. Recent population-based twin and family studies have demonstrated the importance of the hereditary component of cervical cancer, associated with genetic susceptibility. Consequently, SNP markers and microsatellites should be considered genetic factors for determining what combinations of genetic factors are involved in precancerous changes to cervical cancer. This study employs a Bayesian network and four different decision tree algorithms, and compares the performance of these learning algorithms. The results of this study raise the possibility of investigations that could identify combinations of genetic factors, such as SNPs and microsatellites, that influence the risk associated with common complex multifactorial diseases, such as cervical cancer. The web site associated with this study is http://dblab8.csie.ncu.edu.tw/FactorAnalysis/.
Index Terms:
Genetic Factors, Cervical Cancer, Decision tree, Bayesian Network
Citation:
Jorng-Tzong Horng, Kai-Chih Hu, Li-Cheng Wu, Hsien-Da Huang, Horn-Cheng Lai, Ton-Yuen Chu, "Identifying the Combination of Genetic Factors that Determine Susceptibility to Cervical Cancer," bibe, pp.325, Fourth IEEE Symposium on Bioinformatics and Bioengineering (BIBE'04), 2004
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