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Fourth IEEE Symposium on Bioinformatics and Bioengineering (BIBE'04)
Identifying Projected Clusters from Gene Expression Profiles
Taichung, Taiwan, ROC
May 19-May 21
ISBN: 0-7695-2173-8
Kevin Y. Yip, University of Hong Kong
David W. Cheung, University of Hong Kong
Michael K. Ng, University of Hong Kong
Kei-Hoi Cheung, Yale University
In microarray gene expression data, clusters may hide in subspaces. Traditional clustering algorithms that make use of similarity measurements in the full input space may fail to detect the clusters. In recent years a number of algorithms have been proposed to identify this kind of projected clusters, but many of them rely on some critical parameters whose proper values are hard for users to determine. In this paper a new algorithm that dynamically adjusts its internal thresholds is proposed. It has a low dependency on user parameters while allowing users to input some domain knowledge should they be available. Experimental results show that the algorithm is capable of identifying some interesting projected clusters from real microarray data.
Citation:
Kevin Y. Yip, David W. Cheung, Michael K. Ng, Kei-Hoi Cheung, "Identifying Projected Clusters from Gene Expression Profiles," bibe, pp.259, Fourth IEEE Symposium on Bioinformatics and Bioengineering (BIBE'04), 2004
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