A real-time remote arrhythmia monitoring system prototype developed at NASA collects ECG signals from mobile or homebound patients, combines GPS location data, and transmits both to a remote station for display and monitoring. In the end-to-end system architecture, ECG signals are collected from a patient using an event recorder and transmitted to a PDA using Bluetooth, a short-range wireless technology. The PDA concurrently tracks the patient?s location via a connection to a GPS receiver. A long-distance link is established via a standard Internet connection over a 2.5 generation GSM/GPRS cellular, wireless infrastructure. The digital signal is transmitted to a remote computer and viewed using embedded Web technology for monitoring by medical professionals.