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UKSim 2009: 11th International Conference on Computer Modelling and Simulation
Deducing Chemical Reaction Rate Constants and Their Regions of Confidence from Noisy Measurements of Time Series of Concentration
March 25-March 27
ISBN: 978-0-7695-3593-7
We present a new method for estimating rate coefficients from noisy observations of concentration levels at discrete time points. Our inference method is based on a new maximum likelihood approach to the estimation of probability density function of the variations in reactant concentration. The inference procedure returns the rate coefficients with their intervals of confidence, and the variance of noise in the input data.
Index Terms:
parameter inference, biochemical networks
Citation:
Paola Lecca, Alida Palmisano, Corrado Priami, "Deducing Chemical Reaction Rate Constants and Their Regions of Confidence from Noisy Measurements of Time Series of Concentration," uksim, pp.200-205, UKSim 2009: 11th International Conference on Computer Modelling and Simulation, 2009
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