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Electronic Detection of DNA Hybridization: Toward CMOS Microarrays
January-February 2007 (vol. 24 no. 1)
pp. 38-48
Luca Benini, University of Bologna
Carlotta Guiducci, ESPCI-Paris
Christian Paulus, Siemens AG
DNA microarrays are among the key technology enablers for the tumultuous development of biology and medicine triggered by high-throughput genomics. As microarray-based methods for analysis and diagnosis become more pervasive, there is an ever-growing demand for low-cost, highly integrated microarrays for point-of-care usage. This article focuses on fully electronic approaches that integrate DNA sensor arrays and circuits for transduction, amplification, digital conversion, and readout of signals on a single CMOS chip. Prototypes of these devices have obtained promising results.
Index Terms:
CMOS microarrays, DNA hybridization, label-based DNA chip, label-free DNA chip
Luca Benini, Carlotta Guiducci, Christian Paulus, "Electronic Detection of DNA Hybridization: Toward CMOS Microarrays," IEEE Design & Test of Computers, vol. 24, no. 1, pp. 38-48, Jan.-Feb. 2007, doi:10.1109/MDT.2007.12
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