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Issue No.12 - December (2004 vol.15)

pp: 1070-1081

Srinivas Aluru , IEEE

DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/TPDS.2004.86

ABSTRACT

<p><b>Abstract</b>—We present the first space and time optimal parallel algorithm for the pairwise sequence alignment problem, a fundamental problem in computational biology. This problem can be solved sequentially in <tmath> O(mn)</tmath> time and <tmath> O(m+n)</tmath> space, where <tmath> m</tmath> and <tmath> n</tmath> are the lengths of the sequences to be aligned. The fastest known parallel space-optimal algorithm for pairwise sequence alignment takes optimal <tmath> O\left({{m+n}\over{p}}\right)</tmath> space, but suboptimal <tmath> O\left({{(m+n)^2}\over{p}}\right)</tmath> time, where <tmath> p</tmath> is the number of processors. On the other hand, the most space economical time-optimal parallel algorithm takes <tmath> O\left({{mn}\over{p}}\right)</tmath> time, but <tmath> O\left(m+{{n}\over{p}}\right)</tmath> space. We close this gap by presenting an algorithm that achieves both time and space optimality, i.e. requires only <tmath> O\left({{m+n}\over{p}}\right)</tmath> space and <tmath> O\left({{mn}\over{p}}\right)</tmath> time. We also present an experimental evaluation of the proposed algorithm on an IBM xSeries cluster. Although presented in the context of full sequence alignments, our algorithm is applicable to other alignment problems in computational biology including local alignments and syntenic alignments. It is also a useful addition to the range of techniques available for parallel dynamic programming.</p>

INDEX TERMS

Computational biology, sequence alignments, space-efficient, parallel algorithms, parallel dynamic programming.

CITATION

Stjepan Rajko, Srinivas Aluru, "Space and Time Optimal Parallel Sequence Alignments",

*IEEE Transactions on Parallel & Distributed Systems*, vol.15, no. 12, pp. 1070-1081, December 2004, doi:10.1109/TPDS.2004.86