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Multiscale Modelling and Analysis of Planar Cell Polarity in the Drosophila Wing
PrePrint
ISSN: 1545-5963
| ASCII Text | x | ||
| Qian Gao, David Gilbert, Monika Heiner, Fei Liu, Daniele Maccagnola, David Tree, "Multiscale Modelling and Analysis of Planar Cell Polarity in the Drosophila Wing," IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 99, no. 1, pp. 1-1, , 5555. | |||
| BibTex | x | ||
| @article{ 10.1109/TCBB.2012.101, author = {Qian Gao and David Gilbert and Monika Heiner and Fei Liu and Daniele Maccagnola and David Tree}, title = {Multiscale Modelling and Analysis of Planar Cell Polarity in the Drosophila Wing}, journal ={IEEE/ACM Transactions on Computational Biology and Bioinformatics}, volume = {99}, number = {1}, issn = {1545-5963}, year = {5555}, pages = {1-1}, doi = {http://doi.ieeecomputersociety.org/10.1109/TCBB.2012.101}, publisher = {IEEE Computer Society}, address = {Los Alamitos, CA, USA}, } | |||
| RefWorks Procite/RefMan/Endnote | x | ||
| TY - JOUR JO - IEEE/ACM Transactions on Computational Biology and Bioinformatics TI - Multiscale Modelling and Analysis of Planar Cell Polarity in the Drosophila Wing IS - 1 SN - 1545-5963 SP1 EP1 EPD - 1-1 A1 - Qian Gao, A1 - David Gilbert, A1 - Monika Heiner, A1 - Fei Liu, A1 - Daniele Maccagnola, A1 - David Tree, PY - 5555 KW - Ordinary Differential Equations KW - Computer Applications KW - Life and Medical Sciences KW - Biology and genetics KW - Computing Methodologies KW - Simulation KW - Modeling KW - and Visualization KW - Applications KW - Model Validation and Analysis KW - Model Development KW - Simulation Output Analysis KW - Simulation Support Systems KW - Types of Simulation KW - Continuous KW - Pattern Recognition KW - Mathematics of Computing KW - Numerical Analysis VL - 99 JA - IEEE/ACM Transactions on Computational Biology and Bioinformatics ER - | |||
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/TCBB.2012.101
Modelling across multiple scales is a current challenge in Systems Biology, especially when applied to multicellular organisms. In this paper we present an approach to model at different spatial scales, using the new concept of hierarchically coloured Petri Nets (HCPN). We apply HCPN to model a tissue comprising multiple cells hexagonally packed in a honeycomb formation in order to describe the phenomenon of Planar Cell Polarity (PCP) signalling in Drosophila wing. We have constructed a family of related models, permitting different hypotheses to be explored regarding the mechanisms underlying PCP. In addition our models include the effect of well-studied genetic mutations. We have applied a set of analytical techniques including clustering and model checking over time series of primary and secondary data. Our models support the interpretation of biological observations reported in the literature.
Index Terms:
Ordinary Differential Equations,Computer Applications,Life and Medical Sciences,Biology and genetics,Computing Methodologies,Simulation,Modeling,and Visualization,Applications,Model Validation and Analysis,Model Development,Simulation Output Analysis,Simulation Support Systems,Types of Simulation,Continuous,Pattern Recognition,Mathematics of Computing,Numerical Analysis
Citation:
Qian Gao, David Gilbert, Monika Heiner, Fei Liu, Daniele Maccagnola, David Tree, "Multiscale Modelling and Analysis of Planar Cell Polarity in the Drosophila Wing," IEEE/ACM Transactions on Computational Biology and Bioinformatics, 01 Aug. 2012. IEEE computer Society Digital Library. IEEE Computer Society, <http://doi.ieeecomputersociety.org/10.1109/TCBB.2012.101>
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