• Publication
  • PrePrints
  • Abstract - A novel wavelet-based approach for predicting nucleosome positions using DNA structural information
 This Article 
   
 Share 
   
 Bibliographic References 
   
 Add to: 
 
Digg
Furl
Spurl
Blink
Simpy
Google
Del.icio.us
Y!MyWeb
 
 Search 
   
A novel wavelet-based approach for predicting nucleosome positions using DNA structural information
PrePrint
ISSN: 1545-5963
Yanglan Gan, Y. Gan is with the School of Computer Science and Technology, Donghua University, Shanghai, China.(email:ylgan@dhu.edu.cn)
Nucleosomes are basic elements of chromatin structure. The positioning of nucleosomes along a genome is very important to dictate eukaryotic DNA compaction and access. Current computational methods have focused on the analysis of nucleosome occupancy and the positioning of well-positioned nucleosomes. However, fuzzy nucleosomes require more complex configurations and are more difficult to predict their positions. We analyzed the positioning of well-positioned and fuzzy nucleosomes from a novel structural perspective, and proposed WaveNuc, a computational approach for inferring their positions based on continuous wavelet transformation. The comparative analysis demonstrates that these two kinds of nucleosomes exhibit different propeller twist structural characteristics. Well-positioned nucleosomes tend to locate at sharp peaks of the propeller twist profile, whereas fuzzy nucleosomes correspond to broader peaks. The sharpness of these peaks shows that the propeller twist profile may contain nucleosome positioning information. Exploiting this knowledge, we applied WaveNuc to detect the two different kinds of peaks of the propeller twist profile along the genome.We compared the performance of our method with existing methods on real datasets. The results show that the proposed method can accurately resolve complex configurations of fuzzy nucleosomes, which leads to better performance of nucleosome positioning prediction on the whole genome.
Citation:
Guobing Zou, Guangwei Xu, Jihong Guan, Yanglan Gan, "A novel wavelet-based approach for predicting nucleosome positions using DNA structural information," IEEE/ACM Transactions on Computational Biology and Bioinformatics, 28 Feb. 2014. IEEE computer Society Digital Library. IEEE Computer Society, <http://doi.ieeecomputersociety.org/10.1109/TCBB.2014.2306837>
Usage of this product signifies your acceptance of the Terms of Use.