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Si Li , National University of Singapore, Singapore
Kwok Pui Choi , National University of Singapore, Singapore
Taoyang Wu , National University of Singapore, Singapore and University of East Anglia, Norwich
Louxin Zhang , National University of Singapore, Singapore
ABSTRACT
Evolutionary history of protein-protein interaction (PPI) networks provides valuable insight into molecular mechanisms of network growth. In this paper, we study how to infer the evolutionary history of a PPI network from its protein duplication relationship. We show that for a plausible evolutionary history of a PPI network, its relative quality, measured by the so-called loss number, is independent of the growth parameters of the network and can be computed efficiently. This finding leads us to propose two fast maximum likelihood algorithms to infer the evolutionary history of a PPI network given the duplication history of its proteins. Simulation studies demonstrated that our approach, which takes advantage of protein duplication information, outperforms NetArch, the first maximum likelihood algorithm for PPI network history reconstruction. Using the proposed method, we studied the topological change of the PPI networks of the yeast, fruitfly and worm.
INDEX TERMS
History, Proteins, Computational modeling, Biological system modeling, Vegetation, Computational biology, Bioinformatics, maximum likelihood inference, protein-protein interaction network, network evolution
CITATION
Si Li, Kwok Pui Choi, Taoyang Wu, Louxin Zhang, "Maximum Likelihood Inference of the Evolutionary History of a PPI Network from the Duplication History of its Proteins", IEEE/ACM Transactions on Computational Biology and Bioinformatics, , no. 1, pp. 1, PrePrints PrePrints, doi:10.1109/TCBB.2013.14
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