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Application of Dempster-Schafer Method in Family-Based Association Studies
July-Aug. 2013 (vol. 10 no. 4)
pp. 1071-1075
Farid Rajabli, Dept. of Electr. & Electron. Eng., Turgut Ozal Univ., Ankara, Turkey
Unal Goktas, Dept. of Comput. Eng., Turgut Ozal Univ., Ankara, Turkey
Gul Inan, Dept. of Stat., Middle East Tech. Univ., Ankara, Turkey
In experiments designed for family-based association studies, methods such as transmission disequilibrium test require large number of trios to identify single-nucleotide polymorphisms associated with the disease. However, unavailability of a large number of trios is the Achilles' heel of many complex diseases, especially for late-onset diseases. In this paper, we propose a novel approach to this problem by means of the Dempster-Shafer method. The simulation studies show that the Dempster-Shafer method has a promising overall performance, in identifying single-nucleotide polymorphisms in the correct association class, as it has 90 percent accuracy even with 60 trios.
Index Terms:
statistical analysis,diseases,genetics,molecular biophysics,molecular configurations,late onset diseases,Dempster-Schafer method,family based association studies,transmission disequilibrium test,single nucleotide polymorphisms,disease associated SNP,complex diseases,Diseases,Accuracy,Bioinformatics,Genetics,Mathematical model,IEEE transactions,Computational biology,probabilistic algorithms,Algorithm design and analysis,biology and genetics,knowledge and data engineering tools and techniques
Citation:
Farid Rajabli, Unal Goktas, Gul Inan, "Application of Dempster-Schafer Method in Family-Based Association Studies," IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 10, no. 4, pp. 1071-1075, July-Aug. 2013, doi:10.1109/TCBB.2013.85
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