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In Silico Search of DNA Drugs Targeting Oncogenes
Nov.-Dec. 2012 (vol. 9 no. 6)
pp. 1826-1830
G. Papadakis, Dept. of Biol., Univ. of Crete, Heraklion, Greece
E. Gizeli, Dept. of Biol., Univ. of Crete, Heraklion, Greece
Triplex forming oligonucleotides (TFOs) represent a class of drug candidates for antigene therapy. Based on strict criteria, we investigated the potential of 25 known oncogenes to be regulated by TFOs in the mRNA synthesis level and we report specific target sequences found in seven of these genes.
Index Terms:
RNA,cancer,DNA,drugs,genetics,molecular biophysics,target sequences,DNA drugs,oncogenes,triplex forming oligonucleotides,antigene therapy,mRNA synthesis level,DNA,Bioinformatics,Genomics,Encoding,Stability analysis,Cancer,triplex forming oligos,Antigene therapy,oncogenes,transcription inhibition
Citation:
G. Papadakis, E. Gizeli, "In Silico Search of DNA Drugs Targeting Oncogenes," IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 9, no. 6, pp. 1826-1830, Nov.-Dec. 2012, doi:10.1109/TCBB.2012.127
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