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Issue No.03 - May/June (2011 vol.8)
pp: 760-774
Rubén Armañanzas , Universidad Politécnica de Madrid, Madrid
Yvan Saeys , Ghent University, Ghent
Iñaki Inza , University of the Basque Country, San Sebastián
Miguel García-Torres , Pablo de Olavide University, Seville
Concha Bielza , Universidad Politécnica de Madrid, Madrid
Yves van de Peer , Ghent University, Ghent
Pedro Larrañaga , Universidad Politécnica de Madrid, Madrid
ABSTRACT
Progress is continuously being made in the quest for stable biomarkers linked to complex diseases. Mass spectrometers are one of the devices for tackling this problem. The data profiles they produce are noisy and unstable. In these profiles, biomarkers are detected as signal regions (peaks), where control and disease samples behave differently. Mass spectrometry (MS) data generally contain a limited number of samples described by a high number of features. In this work, we present a novel class of evolutionary algorithms, estimation of distribution algorithms (EDA), as an efficient peak selector in this MS domain. There is a trade-of f between the reliability of the detected biomarkers and the low number of samples for analysis. For this reason, we introduce a consensus approach, built upon the classical EDA scheme, that improves stability and robustness of the final set of relevant peaks. An entire data workflow is designed to yield unbiased results. Four publicly available MS data sets (two MALDI-TOF and another two SELDI-TOF) are analyzed. The results are compared to the original works, and a new plot (peak frequential plot) for graphically inspecting the relevant peaks is introduced. A complete online supplementary page, which can be found at http://www.sc.ehu.es/ccwbayes/members/ruben/ms, includes extended info and results, in addition to Matlab scripts and references.
INDEX TERMS
Mass spectrometry, EDA, feature selection, biomarker discovery.
CITATION
Rubén Armañanzas, Yvan Saeys, Iñaki Inza, Miguel García-Torres, Concha Bielza, Yves van de Peer, Pedro Larrañaga, "Peakbin Selection in Mass Spectrometry Data Using a Consensus Approach with Estimation of Distribution Algorithms", IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol.8, no. 3, pp. 760-774, May/June 2011, doi:10.1109/TCBB.2010.18
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