This paper describes the design philosophy for the Grid system being developed by Japan Committee on High-Performance Computing for Bioinformatics and Initiative for Parallel Bioinformatics (IPAB). Grid is one of attractive solutions to achieve distributed bioinformtics environment with high performance parallel computers, large genomic databases, computation intensive applications such as homology search and molecular simulation. However, much has been remained in Grid system design especially in the wide area network environment. OBIGrid emphasizes the virtual organization aspect of the Grid system and gives more priority on security and scalability rather than performance.