This Article 
   
 Share 
   
 Bibliographic References 
   
 Add to: 
 
Digg
Furl
Spurl
Blink
Simpy
Google
Del.icio.us
Y!MyWeb
 
 Search 
   
2012 International Conference for High Performance Computing, Networking, Storage and Analysis
Toward real-time modeling of human heart ventricles at cellular resolution: Simulation of drug-induced arrhythmias
Salt Lake City, UT, USA USA
November 10-November 16
ISBN: 978-1-4673-0805-2
We have developed a highly efficient and scalable cardiac electrophysiology simulation capability that supports groundbreaking resolution and detail to elucidate the mechanisms of sudden cardiac death from arrhythmia. We can simulate thousands of heartbeats at a resolution of 0.1 mm, comparable to the size of cardiac cells, thereby enabling scientific inquiry not previously possible. Based on scaling results from the partially deployed Sequoia IBM Blue Gene/Q machine at Lawrence Livermore National Laboratory and planned optimizations, we estimate that by SC12 we will simulate 8 -- 10 heartbeats per minute -- a time-to-solution 400 -- 500 times faster than the state-of-the-art. Performance between 8 and 11 PFlop/s on the full 1,572,864 cores is anticipated, representing 40 -- 55 percent of peak. The power of the model is demonstrated by illuminating the subtle arrhythmogenic mechanisms of anti-arrhythmic drugs that paradoxically increase arrhythmias in some patient populations.
Index Terms:
Heart,Mathematical model,Logic gates,Instruction sets,Biological system modeling,Equations,Message systems
Citation:
Arthur A. Mirin, David F. Richards, James N. Glosli, Erik W. Draeger, Bor Chan, Jean-luc Fattebert, William D. Krauss, Tomas Oppelstrup, John Jeremy Rice, John A. Gunnels, Viatcheslav Gurev, Changhoan Kim, John Magerlein, Matthias Reumann, Hui-Fang Wen, "Toward real-time modeling of human heart ventricles at cellular resolution: Simulation of drug-induced arrhythmias," sc, pp.1-11, 2012 International Conference for High Performance Computing, Networking, Storage and Analysis, 2012
Usage of this product signifies your acceptance of the Terms of Use.