Orlando, FL, USA
Nov. 14, 1988 to Nov. 18, 1988
pp: 2-12 vol.2
Lander , Harvard Univ., Cambridge, MA, USA
Software tools have been developed to perform rapid large-scale protein sequence comparisons on databases of amino-acid sequences, using a data-parallel computer architecture. This software makes it possible to compare a protein against a database of several thousand proteins in the same time required by a conventional computer to do a single protein-protein comparison, thus enabling biologists to find relevant similarities much more quickly, and to evaluate many different comparison metrics in a reasonable period of time. This software was used to analyze the effectiveness of various scoring metrics in determining sequence similarity, and to generate statistical information about the behavior of these scoring systems under the variation of certain parameters.
software tools, protein sequence comparison metrics, Connection Machine CM-2, databases, amino-acid sequences, data-parallel computer architecture, statistical information, scoring systems
Lander, Mesirov, Taylor, "Study of protein sequence comparison metrics on the Connection Machine CM-2", SC, 1988, SC Conference, SC Conference 1988, pp. 2-12 vol.2, doi:10.1109/SUPERC.1988.74127