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2011 Third International Conference on Knowledge and Systems Engineering
Protein Type Specific Amino Acid Substitution Models for Influenza Viruses
Hanoi, Vietnam
October 14-October 17
ISBN: 978-0-7695-4567-7
| ASCII Text | x | ||
| Nguyen Van Sau, Dang Cao Cuong, Le Si Quang, Le Sy Vinh, "Protein Type Specific Amino Acid Substitution Models for Influenza Viruses," Knowledge and Systems Engineering, International Conference on, pp. 98-103, 2011 Third International Conference on Knowledge and Systems Engineering, 2011. | |||
| BibTex | x | ||
| @article{ 10.1109/KSE.2011.23, author = {Nguyen Van Sau and Dang Cao Cuong and Le Si Quang and Le Sy Vinh}, title = {Protein Type Specific Amino Acid Substitution Models for Influenza Viruses}, journal ={Knowledge and Systems Engineering, International Conference on}, volume = {0}, year = {2011}, isbn = {978-0-7695-4567-7}, pages = {98-103}, doi = {http://doi.ieeecomputersociety.org/10.1109/KSE.2011.23}, publisher = {IEEE Computer Society}, address = {Los Alamitos, CA, USA}, } | |||
| RefWorks Procite/RefMan/Endnote | x | ||
| TY - CONF JO - Knowledge and Systems Engineering, International Conference on TI - Protein Type Specific Amino Acid Substitution Models for Influenza Viruses SN - 978-0-7695-4567-7 SP98 EP103 A1 - Nguyen Van Sau, A1 - Dang Cao Cuong, A1 - Le Si Quang, A1 - Le Sy Vinh, PY - 2011 KW - influenza virus KW - amino acid substitution model KW - phylogeny tree VL - 0 JA - Knowledge and Systems Engineering, International Conference on ER - | |||
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/KSE.2011.23
The amino acid substitution model (matrix) is a crucial part of protein sequence analysis systems. General amino acid substitution models have been estimated from large protein databases, however, they are not specific for influenza viruses. In previous study, we estimated the amino acid substitution model, FLU, for all influenza viruses. Experiments showed that FLU outperformed other models when analyzing influenza protein sequences. Influenza virus genomes consist of different protein types, which are different in both structures and evolutionary processes. Although FLU matrix is specific for influenza viruses, it is still not specific for influenza protein types. Since influenza viruses cause serious problems for both human health and social economics, it is worth to study them as specific as possible. In this paper, we used more than 27 million amino acids to estimate 11 protein type specific models for influenza viruses. Experiments showed that protein type specific models outperformed the FLU model, the best model for influenza viruses. These protein type specific models help researcher to conduct studies on influenza viruses more precisely.
Index Terms:
influenza virus, amino acid substitution model, phylogeny tree
Citation:
Nguyen Van Sau, Dang Cao Cuong, Le Si Quang, Le Sy Vinh, "Protein Type Specific Amino Acid Substitution Models for Influenza Viruses," kse, pp.98-103, 2011 Third International Conference on Knowledge and Systems Engineering, 2011
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