There exists severe wastes in the material handling system of the heavy weight parts machining workshop, which mainly includes the waste of work areas' latency time and the waste of the material handling device's moving distance that caused by frequent circular and reverse routes. To eliminate the waste, a new heavy weight parts machining workshop material lean scheduling method is advanced. The initial universal response scheduling scheme of the heavy weight parts handling system based on genetic algorithm resolves the shortest response route problem when the material handling equipment responds to the requests from all the work areas at the beginning of a workday, which is being restricted to working procedures and the requests of as few as possible blank line. The simulation result shows that the designed new scheduling method is superior to the traditional ones evidently.