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2011 International Conference on Parallel Processing
Parallel Discovery of Direct Causal Relations and Markov Boundaries with Applications to Gene Networks
Taipei City, Taiwan
September 13-September 16
ISBN: 978-0-7695-4510-3
| ASCII Text | x | ||
| Olga Nikolova, Srinivas Aluru, "Parallel Discovery of Direct Causal Relations and Markov Boundaries with Applications to Gene Networks," 2012 41st International Conference on Parallel Processing, pp. 512-521, 2011 International Conference on Parallel Processing, 2011. | |||
| BibTex | x | ||
| @article{ 10.1109/ICPP.2011.49, author = {Olga Nikolova and Srinivas Aluru}, title = {Parallel Discovery of Direct Causal Relations and Markov Boundaries with Applications to Gene Networks}, journal ={2012 41st International Conference on Parallel Processing}, volume = {0}, year = {2011}, issn = {0190-3918}, pages = {512-521}, doi = {http://doi.ieeecomputersociety.org/10.1109/ICPP.2011.49}, publisher = {IEEE Computer Society}, address = {Los Alamitos, CA, USA}, } | |||
| RefWorks Procite/RefMan/Endnote | x | ||
| TY - CONF JO - 2012 41st International Conference on Parallel Processing TI - Parallel Discovery of Direct Causal Relations and Markov Boundaries with Applications to Gene Networks SN - 0190-3918 SP512 EP521 A1 - Olga Nikolova, A1 - Srinivas Aluru, PY - 2011 KW - Bayesian networks KW - constraint-based learning KW - causal relations KW - Markov boundaries VL - 0 JA - 2012 41st International Conference on Parallel Processing ER - | |||
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/ICPP.2011.49
Bayesian networks enable formal probabilistic reasoning on a set of interacting variables of a domain, and have been shown to have broad applicability. More specifically, in bioinformatics Bayesian networks are used to model gene interactions. Learning the structure of a Bayesian network is an NP-hard problem making it necessary to employ heuristics for solving large-scale problems. In this paper, we present parallel algorithms for two problems that arise in relation with network structure learning and analysis: (i) the discovery of all direct causal relations for each variable, i.e., the set of parents and children of each node in the corresponding Bayesian network, and (ii) the computation of Markov boundary of each variable, defined as the minimal set of variables that shield the target variable from all other variables in the domain. Our parallel algorithms are based on state-of-the art constraint-based heuristic optimization methods. They are shown to be work-optimal and communication efficient, and exhibit nearly perfect scaling.
Index Terms:
Bayesian networks, constraint-based learning, causal relations, Markov boundaries
Citation:
Olga Nikolova, Srinivas Aluru, "Parallel Discovery of Direct Causal Relations and Markov Boundaries with Applications to Gene Networks," icpp, pp.512-521, 2011 International Conference on Parallel Processing, 2011
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