Safe and reliable drinking water is vital to every community. But Water pollution incidents have taken place in China frequently resulting in an enormous economic loss. How to solve the problem becomes a significant issue to scrub the deleterious effects of pollution accidents. So the establishment of response models of water pollution accidents in Wuhan city is necessary in order to enhance rapidity, effectiveness and accuracy of emergency commanding, and to improve the level of scientific decision-making. As Emergency pollution management system is a complete system composed of data layer, model layer, the system interface layer and network layer. It also has early warning functions such as the real-time monitoring of water quality and water quality prediction of water pollution accidents. Early Warning and Emergency Response system for Water Pollution Accidents in Wuhan City, China shows a quick-acting and accurate numerical method to calculate the value of pollutant concentration in a short time.