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2008 Second UKSIM European Symposium on Computer Modeling and Simulation
Solving Haplotype Reconstruction Problem in MEC Model with Hybrid Information Fusion
September 08-September 10
ISBN: 978-0-7695-3325-4
| ASCII Text | x | ||
| Ehsan Asgarian, M-Hossein Moeinzadeh, Jafar Habibi, Sarah Sharifian-R, Ammar Rasooli-V, Amir Najafi-A, "Solving Haplotype Reconstruction Problem in MEC Model with Hybrid Information Fusion," Computer Modeling and Simulation, UKSIM European Symposium on, pp. 214-218, 2008 Second UKSIM European Symposium on Computer Modeling and Simulation, 2008. | |||
| BibTex | x | ||
| @article{ 10.1109/EMS.2008.97, author = {Ehsan Asgarian and M-Hossein Moeinzadeh and Jafar Habibi and Sarah Sharifian-R and Ammar Rasooli-V and Amir Najafi-A}, title = {Solving Haplotype Reconstruction Problem in MEC Model with Hybrid Information Fusion}, journal ={Computer Modeling and Simulation, UKSIM European Symposium on}, volume = {0}, year = {2008}, isbn = {978-0-7695-3325-4}, pages = {214-218}, doi = {http://doi.ieeecomputersociety.org/10.1109/EMS.2008.97}, publisher = {IEEE Computer Society}, address = {Los Alamitos, CA, USA}, } | |||
| RefWorks Procite/RefMan/Endnote | x | ||
| TY - CONF JO - Computer Modeling and Simulation, UKSIM European Symposium on TI - Solving Haplotype Reconstruction Problem in MEC Model with Hybrid Information Fusion SN - 978-0-7695-3325-4 SP214 EP218 A1 - Ehsan Asgarian, A1 - M-Hossein Moeinzadeh, A1 - Jafar Habibi, A1 - Sarah Sharifian-R, A1 - Ammar Rasooli-V, A1 - Amir Najafi-A, PY - 2008 KW - null VL - 0 JA - Computer Modeling and Simulation, UKSIM European Symposium on ER - | |||
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/EMS.2008.97
Single Nucleotide Polymorphisms (SNPs), a single DNA base varying from one individual to another, are believed to be the most frequent form responsible for genetic differences. Genotype is the conflated information of a pair of haplotypes on homologous chromosomes. Although haplotypes have more information for disease associating than individual SNPs and genotype, it is substantially more difficult to determine haplotypes through experiments. Hence, computational methods which can reduce the cost of determining haplotypes become attractive alternatives. MEC, as a standard model for haplotype reconstruction, is fed by fragments as input to infer the best pair of haplotypes with minimum error to be corrected. It is proved that haplotype reconstruction in MEC model is a NP-Hard problem. Thus, reducing running time and obtaining acceptable result are desired by researchers. Heuristic algorithms and different clustering methods are employed to achieve these goals. In this paper, the idea of combining different methods is presented. A hybrid model, which is employed the efficiency of different serial and parallel models, is suggested. FCA, K-means and neural network are considered as its component. K-means clustering method is used to improve neural network efficiency. Then the results are compared in different datasets.
Citation:
Ehsan Asgarian, M-Hossein Moeinzadeh, Jafar Habibi, Sarah Sharifian-R, Ammar Rasooli-V, Amir Najafi-A, "Solving Haplotype Reconstruction Problem in MEC Model with Hybrid Information Fusion," ems, pp.214-218, 2008 Second UKSIM European Symposium on Computer Modeling and Simulation, 2008
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