Los Angeles, CA
March 31, 2009 to April 2, 2009
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/CSIE.2009.15
Gene-gene interaction analyses have been used to identify common disease susceptibility genes. Recently, evidence of a statistical interaction among several SNPs has been reported in Crohn's disease. This paper explores the application of Apriori-Gen algorithm on the association study in Crohn's disease. The Apriori-Gen algorithm has been applied to SNP data of Crohn's disease for association study. The result shows the interaction among 5 SNPs with support of 50% and confidence of 60%. The relative risk RR and odds ratio OR are 1.98 and 2.59, respectively. The experiment results indicate that the interaction among those SNPs is responsible for the disease.
Apriori-Gen algorithm, association study, relative risk, odds ratio
Weidong Mao, "The Application of Apriori-Gen Algorithm on the Interaction Analysis of SNPs in Genetic Disease", CSIE, 2009, 2009 WRI World Congress on Computer Science and Information Engineering, CSIE, 2009 WRI World Congress on Computer Science and Information Engineering, CSIE 2009, pp. 626-630, doi:10.1109/CSIE.2009.15