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IEEE Computer Society Bioinformatics Conference (CSB'03)
ANTICLUSTAL: Multiple Sequence Alignment by Antipole Clustering and Linear Approximate 1-Median Computation
Stanford, California
August 11-August 14
ISBN: 0-7695-2000-6
| ASCII Text | x | ||
| C. Di Pietro, V. Di Pietro, G. Emmanuele, A. Ferro, T. Maugeri, E. Modica, G. Pigola, A. Pulvirenti, M. Purrello, M. Ragusa, M. Scalia, D. Shasha, S. Travali, V. Zimmitti, "ANTICLUSTAL: Multiple Sequence Alignment by Antipole Clustering and Linear Approximate 1-Median Computation," Computational Systems Bioinformatics Conference, International IEEE Computer Society, pp. 326, IEEE Computer Society Bioinformatics Conference (CSB'03), 2003. | |||
| BibTex | x | ||
| @article{ 10.1109/CSB.2003.1227333, author = {C. Di Pietro and V. Di Pietro and G. Emmanuele and A. Ferro and T. Maugeri and E. Modica and G. Pigola and A. Pulvirenti and M. Purrello and M. Ragusa and M. Scalia and D. Shasha and S. Travali and V. Zimmitti}, title = {ANTICLUSTAL: Multiple Sequence Alignment by Antipole Clustering and Linear Approximate 1-Median Computation}, journal ={Computational Systems Bioinformatics Conference, International IEEE Computer Society}, volume = {0}, year = {2003}, isbn = {0-7695-2000-6}, pages = {326}, doi = {http://doi.ieeecomputersociety.org/10.1109/CSB.2003.1227333}, publisher = {IEEE Computer Society}, address = {Los Alamitos, CA, USA}, } | |||
| RefWorks Procite/RefMan/Endnote | x | ||
| TY - CONF JO - Computational Systems Bioinformatics Conference, International IEEE Computer Society TI - ANTICLUSTAL: Multiple Sequence Alignment by Antipole Clustering and Linear Approximate 1-Median Computation SN - 0-7695-2000-6 SP EP A1 - C. Di Pietro, A1 - V. Di Pietro, A1 - G. Emmanuele, A1 - A. Ferro, A1 - T. Maugeri, A1 - E. Modica, A1 - G. Pigola, A1 - A. Pulvirenti, A1 - M. Purrello, A1 - M. Ragusa, A1 - M. Scalia, A1 - D. Shasha, A1 - S. Travali, A1 - V. Zimmitti, PY - 2003 KW - Multiple Sequence Alignment KW - Clustering KW - Randomized Tournament VL - 0 JA - Computational Systems Bioinformatics Conference, International IEEE Computer Society ER - | |||
In this paper we present a new Multiple Sequence Alignment (MSA) algorithm called AntiClusAl. The method makes use of the commonly use idea of aligning homologous sequences belonging to classes generated by some clustering algorithm, and then continue the alignment process ina bottom-up way along a suitable tree structure. The final result is then read at the root of the tree. Multiple sequence alignment in each cluster makes use of the progressive alignment with the 1-median (center) of the cluster. The 1-median of set S of sequences is the element of S which minimizes the average distance from any other sequence in S. Its exact computation requires quadratic time. The basic idea of our proposed algorithm is to make use of a simple and natural algorithmic technique based on randomized tournaments which has been successfully applied to large size search problems in general metric spaces. In particular a clustering algorithm called Antipole tree and an approximate linear 1-median computation are used. Our algorithm compared with Clustal W, a widely used tool to MSA, shows a better running time results with fully comparable alignment quality. A successful biological application showing high aminoacid conservation during evolution of Xenopus laevis SOD2 is also cited.
Index Terms:
Multiple Sequence Alignment, Clustering, Randomized Tournament
Citation:
C. Di Pietro, V. Di Pietro, G. Emmanuele, A. Ferro, T. Maugeri, E. Modica, G. Pigola, A. Pulvirenti, M. Purrello, M. Ragusa, M. Scalia, D. Shasha, S. Travali, V. Zimmitti, "ANTICLUSTAL: Multiple Sequence Alignment by Antipole Clustering and Linear Approximate 1-Median Computation," csb, pp.326, IEEE Computer Society Bioinformatics Conference (CSB'03), 2003
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