Mobile computing is popular when wireless network has been deployed almost everywhere. Smartphones have been the important tools in our society for the abundant functions including communication, entertainment and online office etc as the pivotal devices of mobile computing. Smartphone software development has also become more important than before. Android is one of the emerging leading operating systems for smartphones as an open source system platform. Many smartphones have adopted this platform and more smartphones will do so in the future. It is also an emerging problem on how to develop software for smartphones based on Android and those platforms like it. We propose smartphone software development course design based on Android in this paper. What this course focuses is how to teach the development technology to Students. The course design has two parts including the syllabus design and hands-on lab design. At the same time, the innovations are also described in detail and these innovations play a key role in the teaching.