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2011 IEEE International Conference on Bioinformatics and Biomedicine
Inferring Transcript Phylogenies
Atlanta, Georgia USA
November 12-November 15
ISBN: 978-0-7695-4574-5
| ASCII Text | x | ||
| Yann Christinat, Bernard M.E. Moret, "Inferring Transcript Phylogenies," 2012 IEEE International Conference on Bioinformatics and Biomedicine, pp. 208-215, 2011 IEEE International Conference on Bioinformatics and Biomedicine, 2011. | |||
| BibTex | x | ||
| @article{ 10.1109/BIBM.2011.11, author = {Yann Christinat and Bernard M.E. Moret}, title = {Inferring Transcript Phylogenies}, journal ={2012 IEEE International Conference on Bioinformatics and Biomedicine}, volume = {0}, year = {2011}, isbn = {978-0-7695-4574-5}, pages = {208-215}, doi = {http://doi.ieeecomputersociety.org/10.1109/BIBM.2011.11}, publisher = {IEEE Computer Society}, address = {Los Alamitos, CA, USA}, } | |||
| RefWorks Procite/RefMan/Endnote | x | ||
| TY - CONF JO - 2012 IEEE International Conference on Bioinformatics and Biomedicine TI - Inferring Transcript Phylogenies SN - 978-0-7695-4574-5 SP208 EP215 A1 - Yann Christinat, A1 - Bernard M.E. Moret, PY - 2011 KW - alternative splicing KW - transcript KW - evolution VL - 0 JA - 2012 IEEE International Conference on Bioinformatics and Biomedicine ER - | |||
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/BIBM.2011.11
Alternative splicing, an unknown mechanism 20 years ago, is now recognized as a major mechanism for proteome and transcriptome diversity, particularly in mammals -- some researchers conjecture that up to 90% of human genes are alternatively spliced. Despite much research on exon and intron evolution, little is known about the evolution of transcripts. In this paper, we present a model of transcript evolution and an associated algorithm to reconstruct transcript phylogenies. The evolution of the gene structure -- exonsand introns -- is used as basis for the reconstruction of transcript phylogenies. We apply our model and reconstruction algorithm on two well-studied genes, MAG and PAX6, obtaining results consistent with current knowledge and thereby providing evidence that a phylogenetic analysis of transcripts is feasible and likely to be informative.
Index Terms:
alternative splicing, transcript, evolution
Citation:
Yann Christinat, Bernard M.E. Moret, "Inferring Transcript Phylogenies," bibm, pp.208-215, 2011 IEEE International Conference on Bioinformatics and Biomedicine, 2011
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