This Article 
   
 Share 
   
 Bibliographic References 
   
 Add to: 
 
Digg
Furl
Spurl
Blink
Simpy
Google
Del.icio.us
Y!MyWeb
 
 Search 
   
2011 IEEE International Conference on Bioinformatics and Biomedicine
Inferring Transcript Phylogenies
Atlanta, Georgia USA
November 12-November 15
ISBN: 978-0-7695-4574-5
Alternative splicing, an unknown mechanism 20 years ago, is now recognized as a major mechanism for proteome and transcriptome diversity, particularly in mammals -- some researchers conjecture that up to 90% of human genes are alternatively spliced. Despite much research on exon and intron evolution, little is known about the evolution of transcripts. In this paper, we present a model of transcript evolution and an associated algorithm to reconstruct transcript phylogenies. The evolution of the gene structure -- exonsand introns -- is used as basis for the reconstruction of transcript phylogenies. We apply our model and reconstruction algorithm on two well-studied genes, MAG and PAX6, obtaining results consistent with current knowledge and thereby providing evidence that a phylogenetic analysis of transcripts is feasible and likely to be informative.
Index Terms:
alternative splicing, transcript, evolution
Citation:
Yann Christinat, Bernard M.E. Moret, "Inferring Transcript Phylogenies," bibm, pp.208-215, 2011 IEEE International Conference on Bioinformatics and Biomedicine, 2011
Usage of this product signifies your acceptance of the Terms of Use.