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Issue No.04 - October-December (2007 vol.14)
pp: 52-62
Wamiq M. Ahmed , Purdue University
Arif Ghafoor , Purdue University
J. Paul Robinson , Purdue University
ABSTRACT
We present a multilayered architecture and spatiotemporal models for searching, retrieving, and analyzing high-throughput biological imaging data. The analysis is divided into low- and high-level processing. At the lower level, we address issues like segmentation, tracking, and object recognition. At the high level, we use finite-state-machine- and Petri-net-based models for spatiotemporal event recognition.
INDEX TERMS
Spatiotemporal modeling, high-throughput imaging, semantic analysis, high-content screening, and image understanding.
CITATION
Wamiq M. Ahmed, Arif Ghafoor, J. Paul Robinson, "Knowledge Extraction for High-Throughput Biological Imaging", IEEE MultiMedia, vol.14, no. 4, pp. 52-62, October-December 2007, doi:10.1109/MMUL.2007.77
REFERENCES
1. K.A. Giuliano, "High-Content Screening: A New Approach to Easing Key Bottlenecks in the Drug Discovery Process," J. Biomolecular Screening, vol. 2, no. 4, 1997, pp. 249–259.
2. X. Zhou and S.T.C. Wong, "Informatics Challenges of High-Throughput Microscopy," IEEE Signal Processing, vol. 23, no. 3, 2006, pp. 63–72.
3. W.M. Ahmed et al., "Semantic Analysis of Biological Imaging Data: Challenges and Opportunities," Int'l J. Semantic Computing, vol. 1, no. 1, 2007, pp. 67–85.
4. J.C. Venter et al., "The Sequence of the Human Genome," Science, vol. 291, no. 5507, 2001, pp. 1304–1351.
5. D.J. Stephens and V.J. Allan, "Light Microscopy Techniques for Live Cell Imaging," Science, vol. 300, no. 5616, 2003, pp. 82–86.
6. W. Al-Khatib, Y.F. Day, and A. Ghafoor, "Semantic Modeling and Knowledge Representation in Multimedia Databases," IEEE Trans. Knowledge and Data Eng., vol. 11, no. 1, 1999, pp. 64–80.
7. T.R. Jones, A.E. Carpenter, and P. Golland, "Voronoi-Based Segmentation of Cell on Image Manifolds," Proc. Int'l Conf. Computer Vision for Biomedical Image Applications, LNCS 3765, Springer-Verlag, 2005, pp. 535–543.
8. A.K. Jain, R.P.W. Duin, and J. Mao, "Statistical Pattern Recognition: A Review," IEEE Trans. Pattern Analysis and Machine Intelligence, vol. 22, no. 1, 2000, pp. 4–37.
9. E. Meijering, I. Smal, and G. Danuser, "Tracking in Molecular Bioimaging," IEEE Signal Processing, vol. 23, no. 3, 2006, pp. 46–53.
10. Y.F. Day et al., "Object-Oriented Conceptual Modeling of Video Data," Proc. 11th Int'l Conf. Data Engineering, 1995, pp. 401–408.
11. W.M. Ahmed et al., "An XML-Based System for Providing Knowledge-Based Grid Services for High-Throughput Biological Imaging," IEEE Trans. Information Technology in Biomedicine (In press), 2007.
12. J.F. Allen, "Maintaining Knowledge about Temporal Intervals," Comm. ACM, Nov. 1983, pp. 832–843.
13. W.M. Ahmed et al., "FSM-Based Model for SpatioTemporal Event Recognition for HCS," Proc. 1st Int'l IEEE Conf. Semantic Computing, IEEE CS Press, 2007, pp. 569–574.
14. W. Al-Khatib and A. Ghafoor, "An Approach for Video Meta-Data Modeling and Query Processing," Proc. Seventh ACM Int'l Conf. Multimedia (Part 1), 1999, pp. 215–224.
15. J.D. Robertson, S. Orrenius, and B. Zhivotovsky, "Review: Nuclear Events in Apoptosis," J. Structural Biology, vol. 129, nos. 2–3, 2000, pp. 346–358.
16. M. Diakonova et al., "Dynamics of Cytoskeletal Proteins during Fc Receptor-Mediated Phagocytosis in Macrophages," Molecular Biology of the Cell, vol. 13, no. 2, 2002, pp. 402–411.
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