Issue No.03 - May/June (2005 vol.20)
Jianlin Cheng , University of California, Irvine
Pierre Baldi , University of California, Irvine
Eric Mjolsness , University of California, Irvine
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/MIS.2005.51
Sigmoid is a generative, scalable software infrastructure for pathway bioinformatics and systems biology. The Sigmoid modeling system is a three-tier architecture comprising distributed modules that implement pathway and cell model generation and simulation (Cellerator), a pathway-modeling database, Web-services-oriented middleware, and a GUI. Future enhancements will include parameter optimization and other data mining technologies. Key to the infrastructure's design is its scalability, ensured by leveraging symbolic computer algebra and self-generation of database and other code from high-level representations such as UML schema.
cell modeling, bioinformatics, pathway, systems biology, computer algebra, intelligent middleware, generative software, Sigmoid, Cellerator, UML
Jianlin Cheng, Pierre Baldi, Eric Mjolsness, "Sigmoid: A Software Infrastructure for Pathway Bioinformatics and Systems Biology", IEEE Intelligent Systems, vol.20, no. 3, pp. 68-75, May/June 2005, doi:10.1109/MIS.2005.51