By the time you read this column, the Royal Swedish Academy of Sciences will have announced the recipients of this year's Nobel Prizes in Physiology or Medicine, Physics, and Chemistry . The chances are good that computational science contributed to some of the prize-winning work. What tours de force of computational science deserve future Nobels? At the top of my list in medicine is the Human Genome Project. However, given Alfred Nobel's stipulation that no more than three people share a prize, the vast project could miss out. Particle physics discoveries typically involve Herculean feats of number crunching. The Sudbury Neutrino Observatory's (SNO) confirmation in 2001 that neutrinos oscillate in flavor merits a physics prize, a share of which would presumably go to SNO's director, Art McDonald. In chemistry, I favor honoring Harvard's Martin Karplus for pioneering the use of molecular dynamics simulations to elucidate the behavior of proteins and other biomolecules. By the time you read this column, you'll know if any of my predictions came true.