This Article 
 Bibliographic References 
 Add to: 
Simulating the Electro-Mechanical Behavior of Skeletal Muscles
November/December 2010 (vol. 12 no. 6)
pp. 48-58
Oliver Röhrle, SRC Simulation Technology, Stuttgart
Computational models of the human body must be accurate enough to use in hypothesis testing or biological function analysis. This is possible only when such models use physiological information from different scales—such as the cell, tissue, and organ levels. This model of excitation-contraction coupling in skeletal muscles links cell-level electro-physiological behavior with organ-level biomechanical behavior.

1. G. Clapworthy et al., "Editorial," Philosophical Trans. Royal Society A: Mathematical, Physical and Eng. Sciences, vol. 366, no. 1879, 2008, pp. 2975–2978.
2. A.L. Hodgkin and A.F. Huxley, "A Quantitative Description of Membrane Current and Its Application to Conduction and Excitation in Nerve," J. Physiology, vol. 117, no. 4, 1952, pp. 500–544.
3. P.R. Shorten et al., "A Mathematical Model of Fatigue in Skeletal Muscle Force Contraction," J. Muscle Research and Cell Motility, vol. 28, no. 6, 2007, pp. 293–313.
4. C.P. Bradley, A.J. Pullan, and P.J. Hunter, "Geometric Modeling of the Human Torso Using Cubic Hermite Elements," Ann. Biomedical Eng., vol. 25, no. 1, 1997, pp. 96–111.
5. J.B. Davidson, Biophysical Modelling of Skeletal Muscle, doctoral dissertation, Auckland Bioengineering Inst., Univ. Auckland, 2009.
6. O. Röhrle and A.J. Pullan, "Three-Dimensional Finite Element Modelling of Muscle Forces During Mastication," J. Biomechanics, vol. 40, no. 15, 2007, pp. 3363–3372.
7. O. Röhrle, J.B. Davidson, and A.J. Pullan, "Bridging Scales: A Three-Dimensional Electromechanical Finite Element Model of Skeletal Muscle," SIAM J. Scientific Computing, vol. 30, no. 6, 2008, pp. 2882–2904.

Index Terms:
Skeletal muscle modeling, finite elasticity, biodomain equations, cellular modeling, multiscale modeling, excitation-contraction, coupling, scientific computing
Oliver Röhrle, "Simulating the Electro-Mechanical Behavior of Skeletal Muscles," Computing in Science and Engineering, vol. 12, no. 6, pp. 48-58, Nov.-Dec. 2010, doi:10.1109/MCSE.2010.30
Usage of this product signifies your acceptance of the Terms of Use.