|
| This Article | ||
| ||
| Share | ||
| Bibliographic References | ||
| Add to: | ||
 Digg  Furl  Spurl  Blink  Simpy  Google  Del.icio.us  Y!MyWeb | ||
| Search | ||
| ||
| ASCII Text | x | ||
| Reza Toghraee, Kyu-Il Lee, Umberto Ravaioli, "Simulation of Ion Permeation in Biological Membranes," Computing in Science and Engineering, vol. 12, no. 2, pp. 43-47, March/April, 2010. | |||
| BibTex | x | ||
| @article{ 10.1109/MCSE.2010.46, author = {Reza Toghraee and Kyu-Il Lee and Umberto Ravaioli}, title = {Simulation of Ion Permeation in Biological Membranes}, journal ={Computing in Science and Engineering}, volume = {12}, number = {2}, issn = {1521-9615}, year = {2010}, pages = {43-47}, doi = {http://doi.ieeecomputersociety.org/10.1109/MCSE.2010.46}, publisher = {IEEE Computer Society}, address = {Los Alamitos, CA, USA}, } | |||
| RefWorks Procite/RefMan/Endnote | x | ||
| TY - MGZN JO - Computing in Science and Engineering TI - Simulation of Ion Permeation in Biological Membranes IS - 2 SN - 1521-9615 SP43 EP47 EPD - 43-47 A1 - Reza Toghraee, A1 - Kyu-Il Lee, A1 - Umberto Ravaioli, PY - 2010 KW - Ion channel KW - transport Monte Carlo simulation KW - α-Hemolysin KW - grid-focusing method VL - 12 JA - Computing in Science and Engineering ER - | |||
As part of nature's solution for regulating biological environments, ion channels are particularly interesting to device engineers seeking to understand how nanoscale molecular systems realize device-like functions, such as biosensing of organic analytes. By attaching molecular adaptors inside genetically engineered ion channels, it's possible to further enhance this biosensor functionality.
1. B. Hille, Ionic Channels of Excitable Membranes, Sinauer Assoc., 2001.
2. B. Eisenberg, "Ion Channels as Devices," J. Computational Electronics, vol. 2, nos. 2–4, 2003, pp. 245–249.
3. J.D. Watson et al., Molecular Biology of the Gene, 5th Ed., Benjamin/Cummings, 2003.
4. H. Bayley and P.S. Cremer, "Stochastic Sensors Inspired by Biology," Nature, vol. 4, no. 413, 2001, pp. 226–230.
5. T.A. van der Straaten, G. Kathawala, and U. Ravaioli, "Device Engineering Approaches to the Simulation of Charge Transport in Biological Ion Channels," J. Computing and Theoretical Nanoscience, vol. 3, no. 1, 2006, pp. 1–21.
6. R. Hockney and J. Eastwood, Computer Simulation Using Particles, McGraw-Hill, 1981.
7. P.L. Paine and P. Scherr, "Drag Coefficients for the Movement of Rigid Spheres through Liquid-Filled Cylindrical Pores," Biophysical J, vol. 15, no. 10, 1975, pp. 1087–1095.
8. L. Song et al., "Structure of Staphylococcal Alpha-Hemolysin, a Heptameric Transmembrane Pore," Science, vol. 274, no. 5294, 1996, pp. 1859–1869.
9. V. Guillet et al., "Crystal Structure of Leucotoxin S Component: New Insight into the Staphylococcal β-Barrel Pore-Forming Toxins," J. Biological Chemistry, vol. 279, 2004, pp. 41028–41037.
10. J.J. Kasianowicz and S.M. Bezrukov, "Protonation Dynamics of the Alpha-Toxin Ion Channel from Spectral Analysis of pH-Dependent Current Fluctutations, Biophysical J., vol. 69, no. 1, 1995, pp. 94–105.
11. H. Wu et al., "Protein Nanopores with Covalently Attached Molecular Adapters," Am. Chemical Soc., vol. 129, no. 51, 2007, pp. 16142–16148.
12. G. Kathawala and U. Ravaioli, Monte Carlo Simulation of Nanostructures: Semiconductor Devices to Ion Channels, doctoral dissertation, Dept. Electrical and Computer Eng., Univ. Illinois, Urbana-Champaign, 2005.