Information systems, networks, and technologies have become an integral part of modern critical control systems that manage many of today’s critical infrastructures. The continuous operation, maintenance, and protection of critical infrastructures have become a high national priority for governments around the world because our society heavily depends on them for most of our daily activities (travel, power usage, banking transactions, telecommunications, etc) and safety. It is therefore critical that these infrastructures have to be protected from potential accidental incidents or cyberattacks. We present the fundamental architectural components of critical control systems which manage most critical infrastructures. We identify some of the vulnerabilities and threats to modern critical control systems followed by protection solutions that can be deployed to mitigate attacks exploiting these vulnerabilities.