This Article 
   
 Share 
   
 Bibliographic References 
   
 Add to: 
 
Digg
Furl
Spurl
Blink
Simpy
Google
Del.icio.us
Y!MyWeb
 
 Search 
   
BioSig: An Imaging Bioinformatic System for Studying Phenomic
July 2002 (vol. 35 no. 7)
pp. 65-71
Bahram Parvin, Lawrence Berkeley National Laboratory
Qing Yang, LBNL

Using genomic information to understand complex organisms requires comprehensive knowledgeof the dynamics of phenotype generation and maintenance. A phenotype results from selective expression of the genome, creating a history of the cell and its response to the extracellular environment. Defining cell phenomes requires tracking the kinetics and quantities ofmultiple constituent proteins, their cellular context, and their morphologicalfeatures in large populations.

The BioSig imaging bioinformatic system for characterizing phenomicsanswers these challenges. The BioSig approach to microscopy and quantitative image analysis helps to build a more detailed picture of the signaling that occurs between cells as a response toexogenous stimulus such as radiation or as a consequence of endogenous programs leading to biological functions. The system provides a data model for capturing experimental annotations and variables, computational techniques for summarizing large numbers of images, and a distributedarchitecture that facilitates distant collaboration.

Citation:
Bahram Parvin, Qing Yang, Gerald Fontenay, Mary Helen Barcellos-Hoff, "BioSig: An Imaging Bioinformatic System for Studying Phenomic," Computer, vol. 35, no. 7, pp. 65-71, July 2002, doi:10.1109/MC.2002.1016903
Usage of this product signifies your acceptance of the Terms of Use.